Dengue vaccines: closer but not there yet

Closer but not there yet: models in child injury research.

Die—but not just yet

eterochromatin’s repressive hold on DNA transcription can only be relinquished when activators enter the nucleus. Or so the theory goes. But now Vanessa Witte, Andreas Baur (University of Erlangen, Germany), and colleagues find that a heterochromatin component can be pulled from the nucleus by both the HIV protein Nef and activated integrins. “This is a really new concept—that chromatin-associa...

Vpu and BST2: Still Not There Yet?

Extensive investigations have identified two cellular proteins in humans that potently inhibit HIV type 1 (HIV-1) replication and are widely accepted as "restriction factors." APOBEC3G was identified as a restriction factor that diminishes HIV-1 replication by inducing G-to-A hypermutation in the viral genome, while BST2 has been identified as another restriction factor that impairs the release...

On Course, but not There Yet: Enterprise Architecture Conformance and Benefits in Systems Development

Various claims have been made regarding the benefits that Enterprise Architecture (EA) delivers for both individual systems development projects and the organization as a whole. This paper presents the statistical findings of a survey study (n=293) carried out to empirically test these claims. First, we investigated which techniques are used in practice to stimulate conformance to EA. Secondly,...

Eradication of iodine deficiency in Spain. Close, but not there yet.